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While TG serves as a physiological adaptation to excess energy intake, chronic overconsumption of SFAs disrupts lipid homeostasis, leading to ectopic TG accumulation in non-adipose tissues, a phenomenon known as lipotoxicity ( Exposure to SFAs drives macrophage polarization toward a pro-inflammatory M1-like phenotype

The same ultrasound machine was used at initial presentation and in the follow-up examinations (Philips Affinity 70 G), and the ultrasound examination was always performed by the same doctor

References Lpez-Otn, C., Blasco, M

Furthermore, calycosin has been shown to activate the Nrf2/HO-1/NQO-1 pathway, thereby inhibiting the inflammatory response of RA-FLSs