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While a substitution with the polar serine at position 13 retained wild-type dehydratase activity, presumably due to the alcohols ability to assume cysteines function in stabilizing deprotonated GS , the only other Pt GSTF8 variants to keep analbeit reducedflavan-3,3,4-triol ( 4 ) dehydration activity contained a glycine, alanine or asparagine mutation (Fig

Most tumors, both benign and malignant, can be demonstrated to have a clonal origin, being derived from one cell

Gallic acid exhibits various biological properties, with its antioxidant capacity being the most notable (Wianowska and Olszowy-Tomczyk, 2023)

SHH has driven proliferation and migration of different cell types, such as cancer cells (Sari et al., 2018) and oligodendrocyte precursors (Merchn et al., 2007)