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This study demonstrates that AGER-dependent macropinocytosis contributes to drug resistance during RAS-targeted therapy

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A number of small compounds can be used to induce autophagy, for example activation of ROS, blocking ion channels and maturation of the phagosome

doi: 10.3389/fnut.2026.1695902 Received 30 August 2025 Revised 13 January 2026 Accepted 26 January 2026 Published 19 February 2026 Volume 13 - 2026 Edited by Yemin Wang, University of British Columbia, Canada Reviewed by Afreen Saif, King George Medical University, India Le Anh Minh Nguyen, Western University, Canada Jianan Geng, Jilin Agriculture University, China Updates Copyright 2026 Zhang, Xu, Wang, Shen, Sun, Zha and Wang