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Under normal conditions, Fe 2+ is largely imported by membrane iron transport protein (FPN) on the basolateral membrane of the duodenum, where it is oxidized to Fe 3+ and then collected by transferrin (Tf) in plasma (70)

Some of this risk can be mitigated by screening for latent TB, by immunizations against other pathogens and by cancer prevention and screening strategies such as sun avoidance and cervical cytology testing

Key safety principles include strict sterile technique to prevent contamination and infection, proper injection site preparation and rotation, correct needle insertion angle and depth for chosen administration route (IM or SC), slow administration to minimize discomfort, and appropriate post-injection site care and monitoring

These damage could come from toxins, UV rays, and inflammation