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IFN--activated macrophages reduce Cu levels in phagosomes to control the fungal pathogen Histoplamsa capsulatum (White et al., 2009a)

J Frailty Aging

Previous studies have theoretically and experimentally demonstrated the positive therapeutic effects of modulating oxidation in viral CAPs, such as COVID-19, but there is a relative lack of more relevant clinical studies to further clarify the clinical efficacy in CAP infection caused by other pathogens

These findings suggest that loss of PDI functional activity can directly lead to apoptosis, or indirectly, to a range of cellular abnormalities, such as oxidative stress, protein misfolding, as well as cell death (Jeon et al., 2014)