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10.1016/j.ydbio.2019.06.016 73 LinH

IRG1 is highly expressed in inflammation-activated macrophages and catalyzes the conversion of the tricarboxylic acid cycle intermediate cis-aconitate into itaconate

In this study, we performed a double-sample genome-wide association study (GWAS) of BAAs and PD to analyze key SNPs and conducted a Mendelian randomization (MR) study to determine the impact of the expression levels of specific BAA on the pathogenesis of PD in search of biomarkers and blocking targets in the early stages of PD