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Guo F et al

the mechanisms exploited involve interventions on the RAS system [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs)], vasodilation induced by direct vasodilators [calcium channel blockers (CCBs) such as dihydropyridine], the reduction in atrioventricular conduction (beta-blockers, CCBs such as phenylalkylamine, benzothiazepine), or diuretic actions capable of reducing electrolyte levels, particularly Na + (including loop diuretics, thiazides, and potassium sparing)

Oral contraceptives: May lower serum vitamin B12 concentrations (34)

Our findings indicate that control adult rats demonstrated improved learning and memory after caffeine and paraxanthine administration, which may suggest a heightened stress level among these animals