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Six children suffering from radiation-induced GHD treated with GH between 3 and 10 years after cranial irradiation exhibit a mean growth during the pretreatment year of 3.7 cm and during the first year of GH therapy is 7.9 cm, indicating the recovery effect of GH on radiation damage (Shalet et al., 1981)

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An enzyme-linked immunosorbent analysis showed that the higher cytokine secretion levels of IFN-, TNF- and interleukin 6 (IL-6, a critical modulator of innate immunity) in the AP20187 treated group compared to age-matched vehicle-treated controls could be observed