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Under the inducement of diverse stimuli and the activation by various cellular signals, GSDM proteins are subjected to proteolytic cleavage, and the oligomerized N-terminal domain of GSDM proteins is allowed to penetrate the cell membrane and cause rapid plasma membrane rupture, thus releasing proinflammatory mediators such as IL-18 and IL-1 [33, 65]

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2.1 Oxidative stress and ethanol metabolites Alcohol is metabolized in the liver by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1), and catalase, concurrently generating reactive oxygen species (ROS) and leading to oxidative stress (Yang et al., 2022)