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10.1155/2013/781348 9 FelkerD.LynnA.WangS.JohnsonD

The overexpression of Sirt1 has been reported to reduce S aggregation and promote the survival of dopaminergic neuronal cells (Guo et al., 2016), while a small molecule Sirt1 agonist has been found to protect neurons from cell death in a PD animal model ((Lofrumento et al., 2014)