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submitted an application for new technology add-on payments for SER-109 for FY 2024

N-acetylcysteine (NAC), a precursor of reduced glutathione (GSH), has been widely used as an antioxidant against reactive oxygen species (ROS) in several disorders related to oxidative stress [8], in addition to its applications in ischemiareperfusion injury, acute respiratory distress syndrome and chemotherapy-induced toxicity [13,14,15], NAC has also been proposed as an anticancer agent in vitro and in vivo either stand-alone or as an adjuvant to reduce aggressiveness in several cancers [16, 17]

vii , viii Conversely, studies in numerous species of animals have shown that boosting glutathione levels results in better health and increased longevity, and analyses in humans indicate that higher glutathione levels are associated with better health and increased longevity

doi: 10.1002/mds.25772 132 PerinM