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for example, estimated K i values for the tertiary amine TCAs amitriptyline and imipramine are 31.0, 28.6 M, respectively, with K i s for nortriptyline and desipramine being 7.9 and 12.5 (Shin et al., 2002)

Furthermore, intestinal epithelial cells in CD patients exhibit marked overexpression of vacuolar protein sorting 4B (VPS4B) and glycinamide ribonucleotide formyltransferase (GART), both of which modulate apoptotic processes through p38 MAPK pathway activation [55, 56]

350 However, the protective effect of high-fiber diet may be reversed if there exists colonization of Prevotella copri , which leads to the overproduction of organic acids, including fumarate and succinate, during the digestion of complex fibers and the promotion of proinflammatory responses in macrophages, exacerbating arthritis in an RA model

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