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A common variant, C677T , can reduce this conversion by up to 70% in people with two copies of the mutation (Frosst et al., 1995)

However, it is worth noting that there is a possibility that some Sucrosomial B12 may enter the bloodstream in its intact form and potentially be released at the hepatocytes, this aspect of its absorption and metabolism requires further investigation

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In adults and older children, the total volume used should also stay within safe limits animal studies suggest up to about 30 mL (the full vial) can be given to an adult without benzyl-alcohol toxicity, but one should still use only the amount needed and discard the rest if sterility is lost