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Topical treatments include topical steroids, topical calcineurin inhibitors (such as tacrolimus or pimecrolimus), and topical vitamin D analogs (such as calcipotriene)

About this chapter Cite this chapter Sousa, T., Reina-Couto, M., Gomes, P

Tumor-educated macrophages (TEM) present alterations in polyamines, lipid metabolism, and adenosine accumulation

Pathologically, -Syn is subjected to a conformational change from -helical state to -sheet-rich oligomers and fibrils capable of aggregation due to mutations in its encoding gene SNCA, altering SNCA gene transcription and mRNA stability or processing (Nalls et al., 2019