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Non-reduced Capillary Electrophoresis-Sodium Dodecyl Sulfate (CE-NR) analysis was performed with a LabChip GXII Touch HT instrument (PerkinElmer, Waltham, MA, USA)

Capivasertib has shown promising results in combination with ET, by improving PFS in patients with disease progression under prior treatments 127,128

At low ammonia concentrations, cells typically undergo a sub-lethal apoptotic response, a mechanism designed to eliminate mildly damaged cells (113)

This might be because GSTP1 polymorphism led to drug resistance and thus protected the cells, as previously shown in the study by Rocha et al .[] In addition, this result might also be due to an increased expression level of GSTP1 enzyme in the lungs, placenta, lymphocytes, and erythrocytes and low efficacy in the epithelial cells.[] Hemorrhagic cystitis develops due to viral infections of the urinary system or due to exposure to direct toxicity as part of the preparation regimen