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It simultaneously engages several signaling pathways, including those regulated by AKT/PI3K/mTOR pathway, Wnt/-catenin pathway, Yap/Taz pathway, Hedgehog and NF-B (Figure 2)

This dysfunction, in turn, may play a role in the increased vulnerability to vascular disease and T2DM observed within this particular cohort

Three animals per cage were allocated under controlled environmental conditions