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Most patients rate the discomfort as mild to moderate depending on the treatment type used

J Pharmacol Exp Ther 273(2):637642 [PubMed] [Google Scholar] Cognato GP, Agostinho PM, Hockemeyer J, Mller CE, Souza DO, Cunha RA (2010) Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life