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"Mechanisms of Action and Clinical Efficacy of Cagrilintide in Obesity Treatment." Journal of Endocrinology and Metabolism, 45(3), 178-195

the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)