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Vedolizumab: Potential Mechanisms of Action for Reducing Pathological Inflammation in Inflammatory Bowel Diseases

According to research results, the treatment group could effectively reduce the level of TGF- 1 and CTGF, which might provide clinical evidence for early prevention and treatment of A on C patients

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and downregulates PI3K/Akt and mTOR pathway [125, 126], involved in regulating a variety of processes including insulin signaling, cell proliferation, and survival [127]