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Abbreviations CQ: Chloroquine HCQ: Hydroxychloroquine COVID-19: novel Severe Acute Respiratory Syndrome Corona Virus 2 RA: Rheumatoid Arthritis SLE: Systemic Lupus Erythematosus CYP: cytochrome P450 S9: Metabolic activation system +: Positive effect : Weakly positive effect -: Negative (non mutagenic) effect MU: Mutagenicity assay CA: Chromosomal aberrations SCE: Sister-Chromatid Exchang SRL: Sex linked recessive lethals DD: DNA Damage DR: Inhibition of DNA Repair MN: Micronuclei formation CO: Carcinogenicity IL: Interleukin TLR: Toll-like receptor PBMC: Peripheral blood mononuclear cells TNF: Tumor necrosis factor NFAT: Nuclear Factor of Activated T-cells cGAS: Cyclic GMP-AMP synthase STING: Stimulator of interferon genes ACE2: Angiotensin-converting enzyme 2 GM-CSF: Granulocyte-colony stimulating factor References van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, et al