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Known binding partners for CCR5 include, for example, PRAF2, CCL4, GRK2, ARRB1, ARRB2, and The term "CCR 5" is intended to include fragments, variants (e.g., allelic variants), and derivatives thereof

Several ISGs with antiviral function such as the dsRNA-dependent protein kinase R (PKR), viperin, tetherin, zinc-finger antiviral protein and 25 oligoadenylate synthetase (OAS) have been implicated in restricting herpesviruses, but their contribution remains to be elucidated (reviewed in Refs