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Here, we show that consumption of a common non-nutritive sweetener, sucralose, modifies microbiome composition, restricts T cell metabolism and function, and limits immunotherapy response in preclinical models of cancer and advanced cancer patients treated with anti-PD-1 based immune checkpoint inhibitors (ICIs)

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Enzymatic assay Snap-frozen quadriceps muscles from V-CNT ( n = 7) and SUPP ( n = 8) mice were used for citrate synthase (CS) activity, a marker of mitochondrial content [28]

It is best taken with or immediately after a meal, as some of its active ingredients are fat-soluble and absorb much better when taken with food