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Notably, C57BL/6 male mice that received sulforaphane in conjunction with depression-inducing lipopolysaccharide, exhibited lower depressive behaviours on the tail-suspension test and forced swimming test compared to those that did not receive sulforaphane (Zhang et al., 2017)

Cycling Considerations Most protocols recommend cycling off after 12 to 16 weeks to prevent potential receptor desensitization and maintain hormonal sensitivity