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However, under pathological stressors such as chronic inflammation or oxidative stress, -synuclein undergoes conformational rearrangement: -helices destabilize, enabling transition into -sheet-rich oligomers 47,48

A reduction in glutathione levels in the lens has been associated with cataract formation as well as changes in the permeability of the lens that make it harder for nutrient exchange to occur[13], [14]