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Miyashiro et al., 2003

The development of airway remodeling may not be solely due to local airway inflammation

SIRT2 enhances the deacetylation of Smad2 at Lys451 and Smad3 at Lys341 and Lys378 to inhibit the activation of Smad2 and Smad3 and mitigate kidney injury in a UUO mice model and DKD patients (Yang et al., 2023)