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Mice were chronically exposed to filtered air for control group or to CS (20 cigarettestwice/day, 6 days/week) from Marlboro cigarettes (Philip Morris Companies, 0.8 mg of nicotine, 10 mg of tar, and 10 mg of carbon monoxide per cigarette) for the other groups

Whether the same expression shifts occur in living humans at any given dose and route is an assumption, not a demonstrated fact

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A few times weekly at moderate concentrations, year after year, keeps the remodelling signals steady and the MMP/TIMP balance intact