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It works by inhibiting the activity of tyrosinase, the enzyme responsible for melanin production

M1 and M2 macrophage phenotypes A classification system in which heterogeneous macrophages are grouped as either M1, which defines activated pro-inflammatory macrophages associated with protection against bacteria and viruses, and M2, which are alternatively activated macrophages that express different markers and are associated with wound healing and immune suppression

doi: 10.1172/JCI135536 94 BerthierCCZhangHSchinMHengerANelsonRGYeeBet al

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