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Constipation is the most frequent autonomic feature affecting PD individuals and is determined by both neurogenic and non-neurogenic factors, such as reduced mobility and abdominal muscle tone, a diet poor in fibers and insufficient fluid intake, all contributing to a prolonged gastrointestinal transit time and sometimes megacolon [251]

There is also an evidence suggesting inhibition of noradrenaline and dopamine reuptake by fluoxetine (Pozzi et al., 1999

Unlike injectable versions that enter circulation directly, oral capsules rely on advanced delivery systems to maintain efficacy

2 Biological functions of DPP1 and NSPs 2.1 Structural and functional characteristics of DPP1 DPP1 functions as a lysosomal cysteine protease with an approximate molecular weight of 200 kDa, characterized by a distinctive tetrameric architecture