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Int J Mol Sci 21(9) Li L, Tan J, Miao Y et al (2015) ROS and autophagy: interactions and molecular regulatory mechanisms [J]

360 Unlike RTKs, non-receptor tyrosine kinases do not require binding to extracellular ligands for activation and directly participate in regulating signaling pathways by phosphorylating target proteins

Bioresour Technol 101:28452852

PI3K/mTOR inhibitors induce synergistic anti-proliferative and pro-apoptotic effects by inhibiting the kinase activity of the CDK/cyclin complex and, consequently, preventing phosphorylation of the Rb protein (Cretella et al