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At steady state, post-dose peak levels are 2.2 to 2.5 times higher than concentrations produced by the first dose

However, there may be a slight decrease in the clearance of R-warfarin in the elderly as compared to the young

Furthermore, the interaction of ACTL6A with GCLC promoter was weakened by NRF2 KD, and likewise, the interaction of NRF2 with GCLC promoter was weakened by ACTL6A KD (Fig