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Conversely, in IL-6 trans-signaling, soluble forms of IL-6R (sIL-6R), produced through either alternative splicing or limited proteolytic processing, form complexes with IL-6, thereby initiating the activation of membrane-bound gp130

On the other hand, pro-apoptotic miRNAs, like the let-7 and miR-15 families, are downregulated, thus inhibiting apoptosis and promoting tumor progression (Mahboobnia et al