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Multi-center, randomized, placebo-controlled trials of epitalon, BPC-157, TB-500, and Semax in elderly populations could definitively establish efficacy and safety, potentially bringing these agents into mainstream gerontological practice (Wang et al., 2022)

Nevertheless, several of these aspects have been successfully sorted out over recent years through the new technologies available in peptides design field: new bioinformatics tools in combination with other approaches such as virtual screening, structure-based drug design, high throughput screening (HTS) and chemical strategies, provide a comprehensive pharmacological description of putative peptides, improving their chemical and physical features (119, 121, 148)

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