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Besides its alkylating effect, TMZ has other cellular functions, including cell death, carried out by increasing the level of ROS (Zhang et al., 2010) and controlling autophagy (Yan et al., 2016), apoptosis (Roos et al., 2007), and HIF-1 activity (Lo Dico et al., 2018)

However, data in literature are not yet entirely in favor of its use, as demonstrated by recent work in which researchers advise to be careful in considering the measurement of serum zonulin as a marker of the integrity of the intestinal barrier, states Prof

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis