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K-means clustering was done on the relative community abundances using the stats package (v4.3.0) and the average distance within cluster was calculated to assess similarity

For you, though, the most noticeable indication that your body is running low on fluids is likely the feeling of thirst, as you increasingly feel like you need to drink some water

Energy metabolism: B12 helps your body convert food into usable energy, which is one reason low levels can leave you feeling drained

If it was exposed to heat during shipping or storage, or if it is well past its expiration date, the lyophilized powder may have undergone chemical changes that prevent proper dissolution