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Efficacy and safety of an investigational single-course CRISPR base-editing therapy targeting PCSK9 in nonhuman primate and mouse models

10.1186/s13048-024-01344-0 82 HuangC.ZhaoS.YangY.GuoT.KeH.MiX.et al (2023)

Interestingly, hepatic ER requires both estrogen binding and nutrient-dependent stimulation for its full transcriptional activation, thus acting as a metabolic checkpoint that blocks reproductive progression when amino acid intake is insufficient [2]