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Before lcFAODs were included in newborn screening (NBS) panels, a considerable number of patients was diagnosed in adulthood and these patients typically presented with different clinical presentations compared to patients who presented during childhood

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probiotic treatment significantly suppressed these neuroinflammatory pathways ( Moreover, SCFAs and tryptophan metabolites, as key mediators of bidirectional gut-brain communication, play essential roles in maintaining intestinal barrier integrity, modulating immune function, and transmitting signals via the vagus nerve (Pan et al., 2025)

Studies show carnitine deficiencythough rare in healthy adultscorrelates with reduced exercise-induced fat loss and slower metabolic adaptation