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Methylation burden & metabolic dysfunction research: Laboratory applications in cellular methylation stress, SAM-cycle imbalance and NAD+ salvage engineering

Unfortunately, its also one of the vitamins that people are most likely to be deficient in, especially if they are vegetarian or vegan, are over 50, or have conditions that affect absorption

This means that instead of these macronutrients going unused, B12 helps them fuel your body for extra energy

If folate deficiency is suspected, it is reasonable to give oral folic acid (0.4 1 mg/day) without doing laboratory investigation for deficiency at least until the hemoglobin and mean corpuscular volume normalizes (or longer if the underlying cause cannot be eliminated)