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4025-A COMBINATION OF RADIATION THERAPY IMPROVE EFFICACY OF ATEZOLIZUMAB PLUS BEVACIZUMAB (ATE+BEVA) THERAPY IN ADVANCED HEPATOCELLULAR CARCINOMA WITH HIGH RISK FACTOR (HUGE TUMOR, BILIARY AND MAIN PORTAL VEIN INVASION) Sangyoun Hwang, Wan Jeon, Hyung Jun Kim, Jung Woo Im, Ki Jeong Jeon and Beom Jin Shim, Dongnam Institute of Radiological & Medical Sciences Background: Atezolizumab plus bevacizumab (Ate+Beva) proved better efficacy compared to sorafenib as a first line systemic therapy for advanced hepatocellular carcinoma (HCC)

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Other factors like competition from other amino acids, reduced uptake by cationic amino acid transporters (CATs), and elevated arginase activitycommon in conditions such as hypertension and diabetescan limit L-arginine availability to eNOS, diverting it away from NO production (McDonald et al., 1997a