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Among these, coumarin and L-leucine showed the highest test statistics and lowest p-values, indicating stronger group separation relative to other metabolites, while L-octanoylcarnitine and kaempferol exhibited more moderate but consistent differences

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As the main transcription factor of Th17 cell, RORt collaborates with other transcription factors, such as ROR, IRF4, and Runx1, to synergistically stimulate Th17 cell growth and IL-17 release ( Foxp3 interacts with several transcription factors, such as STAT5, NFAT, and BACH2, to influence the Treg cells' development, stability, and epigenetic modifications

Future studies are needed to understand factors that affect patient perception and completion of AUD treatment, which may differ based on severity of disease