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While resmetirom remains the only FDA-approved therapy to date, experimental agents such as elamipretide (SS-31) and uncoupling protein 2 (UCP2) modulators are under investigation to restore mitochondrial integrity and reduce ROS production [103106]

Publisher : The Journal of Undergraduate Neuroscience Education (JUNE)

Photo(chemo)therapy reduces circulating Th17 cells and restores circulating regulatory T cells in psoriasis

It is also possible that mutation of S2 site residues could alter indirectly a putative cryptic binding site at the oligomeric interface especially as these mutants affect oligomerisation in our cell-based assays (Supplementary Fig