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Somatostatin secretion is perturbed in animal models of diabetes mellitus, which might explain the loss of appropriate hypoglycaemia-induced glucagon secretion, a defect that could be mitigated by somatostatin receptor 2 antagonists

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Proteomic analyses further complement these approaches by revealing the active enzyme machinery involved during biodegradation

Effect of the dual glucosedependent insulinotropic peptide/gulcagonlike peptide 1 receptor agonist tirzepatide on lipid profile and waist circumference: a systematic review and metaanalysis