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In December 2024, the FDA's Pharmacy Compounding Advisory Committee declined to include it on the 503A bulk drug substances list, meaning compounding pharmacies in the United States cannot legally produce it for individual prescriptions

Recent investigations (Kwon et al.) have identified AOD 9604 as a chondroprotective agent

It's crucial to note that Tesofensine can cause an increase in heart rate and blood pressure, although these changes have generally been modest in clinical trials