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48 Noteworthy, several analytical techniques are applicable for characterizing the modified drug/CD complexes in the solid state, including thermo-analytical techniques (Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Hot-stage microscopy (HSM)), X-ray diffraction (Single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD)), Spectroscopic techniques (Fourier-transform infra-red (FT-IR) spectroscopy, Attenuated total reflectance (ATR)-FTIR spectroscopy, and Raman spectroscopy), and Scanning electron microscopy (SEM)

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This rule creates the positive list and is limited to the 10 items that were the subject of a proposed final rule on December 15, 2016

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