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Balaji M, Sasikala K

This mechanism-based inhibition of GSTZ1-1 by DCA results in the slowed clearance not only of DCA, but also of the endogenous substrates MAA and MA

However, LAC combined with clozapine was found to not significantly improve the treatment effect of schizophrenic patients who were tolerant to clozapine (73) (Studies are summarized in Table 4)