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BAs act in the brain by interacting with key receptors on neurons and glial cells-Farnesoid X receptor (FXR), Takeda G protein receptor 5 (TGR5), GR, and sphingosine-1-phosphate receptor 2 (S1PR2

Insulin signaling affects particularly Sirt1 and Sirt3

Prognosis of gamma-glutamylcysteine synthetase deficiency, gamma-glutamyl transpeptidase deficiency, 5-oxoprolinase deficiency and dipeptidase deficiency is unclear and difficult to predict as very few patients have been reported worldwide

Figure 7 3.3.5 Microbiota-based interventions 3.3.5.1 Psychobiotics Psychobiotic interventions targeting the MGBA show promise for reversing stress-induced behavioral and physiological dysfunctions