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For example, SIRT2 acts as an eraser by removing multiple acyl marks from both histone and nonhistone proteins [175,176,177,178,179], and several metabolic enzymes implicated in disease pathogenesis are known to modulate more than one modification [180]

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The study by Hughes and Fedirko 38 indicated that a selenium status below 80 g/L could be a risk factor for colorectal cancer risk as elevated selenoprotein concentrations were inversely connected with colorectal cancer risk, which correlated more closely in women than in men

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