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The animals fed a selenium-deficient diet recapitulated some of the pathological manifestations of KBD, strongly supporting the notion that selenium deficiency is critically associated with the development of this endemic arthropathy

Regularly, astrocytes are the main source of NO, however, it has been shown that NT2 neurons can produce NO and therefore increase levels of cGMP (Denninger and Marletta, 1999)

Zinc plays a vital role in maintaining the homeostasis of intestinal epithelial cells, and its deficiency can lead to alterations in their integrity and function

Therapeutic strategies targeting oxidative stress in cancer are being explored, given the critical role of free radicals in tumor biology