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The most compelling mechanism is its proven ability to induce angiogenesisthe formation of new blood vessels

PMID: 39030423 Nat Cell Biol Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression

Whatever the underlying cause of hyperinsulinemia, the result is a reduction in glucose uptake by the muscles and an increase in the production of liver glycogen, which aids in the progress of T2D [36], [85], [86,87,88,89]