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Massive accumulation of intracellular fumarate caused by the inactivation of fumarate hydratase decreases GPX4 activity through posttranslational modification, which further increases the sensitivity of ccRCC to ferroptosis[86]

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This had no impact on the peer review process and the final decision Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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