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Musteikyte G, et al

Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and in vitro

Notably, cGAS- and BAX-dependent microglial senescence was exacerbated by the combined presence of the APOE4 allele and the TREM2 R47H variant, indicating both associated with increased risk and earlier onset of Alzheimer's disease and their potential role as upstream modulators of AD pathogenesis (Carling et al., 2024)